Ex DEA agent Jack receives an emergency message from his brother Phillip, whose team was ambushed on the Caribbean island of St. Keith. Jack goes to St. Keith to find his brother, who has been turned into a cyborg by the drug runner he was after.
A shape shifter (Burke) comes from the desert in search of victims, a spirit the locals call "The Dust Devil". He prays on the lonely and the unloved, those that have already lost everything but life itself. Wendy (Field) has broken up with her husband and wanders aimlessly in her car. She picks up a stranger and begins having misgivings about picking him up when strange things begin to occur. Meanwhile a local police officer (Mokae) tracks the killer. Aided by a shaman's admonishments about witchcraft he sets off to try and stop the beast before it can complete its grisly task.